UvA - DARE ( Digital Academic Repository ) Efficiency of parental chromosome analysis in couples with recurrent miscarriage
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BACKGROUND Preimplantation genetic diagnosis (PGD) has been stated to improve live birth rates compared with natural conception in couples with recurrent miscarriage (RM) carrying a structural chromosome abnormality. It is unclear to what extent this claim can be substantiated by evidence. A systematic review of the literature was performed on the reproductive outcome of these couples after nat...
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متن کاملClinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage.
BACKGROUND The annual number of parental karyotypes in cases of repeated miscarriage is increasing gradually in The Netherlands. The efficiency of offering parental karyotyping in couples with repeated miscarriage has not been evaluated before, especially not for the group with miscarriages at advanced maternal age. METHODS A historical cohort study and nested case-control study were conducte...
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